L-368,899
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|---|---|
| Systematic (IUPAC) name | |
| (S)-2-amino-N-((1S,2S,4R)-7,7-dimethyl-1-((4-o-tolylpiperazin-1-ylsulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide | |
| Identifiers | |
| CAS number | 148927-60-0 |
| ATC code | ? |
| PubChem | CID 132857 |
| Chemical data | |
| Formula | C26H42N4O5S2 |
| Mol. mass | 554.260 g/mol |
| SMILES | eMolecules & PubChem |
| Therapeutic considerations | |
| Pregnancy cat. | ? |
| Legal status | ? |
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L-368,899 is a drug used in scientific research which acts as a selective antagonist of the oxytocin receptor, with good selectivity over the related vasopressin receptors. Unlike related drugs such as the peripherally selective L-371,257, the oral bioavailabity is high and the brain penetration of L-368,899 is rapid, with selective accumulation in areas of the limbic system. This makes it a useful tool for investigating the centrally mediated roles of oxytocin, such as in social behaviour and pair bonding, and studies in primates have shown L-368,899 to reduce a number of behaviours such as food sharing, sexual activity and caring for infants, demonstrating the importance of oxytocinergic signalling in mediating these important social behaviours.
References
Retrieved from : http://en.wikipedia.org/wiki/L-368,899
