Kupe virus
| Kupe virus | |
|---|---|
| Virus classification | |
| Group: | Group V ((-)ssRNA) |
| Order: | Unassigned |
| Family: | Bunyaviridae |
| Genus: | Nairovirus |
| Species | |
| Kupe virus | |
Kupe virus is a virus in the genus Nairovirus, family Bunyaviridae.
Taxonomy
Ganjam virus lies within the Nairobi sheep disease serogroup.
History
The virus was isolated from pooled ticks ( and ) collected from cattle hides in Nairobi, Kenya, in October 1999. The word 'Kupe' is Kiswahili for tick.
Genome
The genome is composed a single strand of negative sense RNA in three parts - small (S), medium (M0 and large(L).
The L segment RNA is 12,330 nucleotides (nt) in length and encodes one open reading frame (ORF) of 4,050 amino acids. There is a non coding regions: the 5′ region of 40 nt and the 3′ region of 137 nt. This open reading frame encodes several modules including a RNA-dependent RNA polymerase. It is probably post translationally cleaved into several proteins but this has yet to be shown.
The M segment RNA is 4,818 nucleotides in length and contains one open reading frame flanked by 5′ and 3′ non coding regions of 47 and 121 nucleotides respectively. The ORF encodes a protein of 1549 amino acids with 8 potential sites for N-linked glycosylation. It contains a unique potential N-gly site in the Gn and Gc glycoprotein regions at amino acids 612 and 1514 respectively.
The S segment has 1,694 nt and encodes an ORF of 483 amino acids. The 5′ and 3′ noncoding regions are 49 nt and 193 nt in length respectively.
References
Retrieved from : http://en.wikipedia.org/wiki/Kupe_virus
