Beta-ketothiolase

Acetyl-CoA C-acyltransferase

acetyl-CoA C-acyltransferase
Identifiers
EC number	2.3.1.16
CAS number	9029-97-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

The final step of beta oxidation is the cleavage of by the thiol group of another molecule of CoA. This reaction is catalyzed by Acetyl-CoA C-acyltransferase (or Β-ketothiolase). The thiol is inserted between C-2 and C-3, which yields an acetyl CoA molecule and an acyl CoA molecule, which is two carbons shorter.

Acetyl-CoA C-acyltransferase belongs to the thiolase family of enzymes.

Examples

Human genes that encode acetyl-CoA C-acyltransferases include:

acetyl-CoA acyltransferase 1 (peroxisomal) Identifiers Symbol ACAA1 Entrez 30 HUGO 82 OMIM 604054 RefSeq NM_001607 UniProt P09110 Other data EC number 2.3.1.16 Locus Chr. 3 p23-p22

acetyl-CoA acyltransferase 2 (mitochondrial) Identifiers Symbol ACAA2 Entrez 10449 HUGO 83 OMIM 604770 RefSeq NM_006111 UniProt P42765 Other data EC number 2.3.1.16 Locus Chr. 18 q21

hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit Identifiers Symbol HADHB Entrez 3032 HUGO 4803 OMIM 143450 RefSeq NM_000183 UniProt P55084 Other data EC number 2.3.1.16 Locus Chr. 2 p23

External links

• MeSH Acetyl-CoA+C-Acyltransferase

Retrieved from : http://en.wikipedia.org/wiki/Acetyl-CoA_C-acyltransferase