2011-03-29

Glucose fatty-acid cycle

Randle cycle

The Randle cycle is a metabolic process involving the competition of glucose and fatty acids for substrates. It is theorized to play a role in explaining type 2 diabetes and insulin resistance.

It is named for Philip Randle, who described it in 1963.

References

  1. Bevilacqua S, Buzzigoli G, Bonadonna R, et al (1990). "Operation of Randle's cycle in patients with NIDDM". Diabetes 39 (3): 383–9. doi:10.2337/diabetes.39.3.383. PMID 2307295.
  2. Shuldiner AR, McLenithan JC (2004). "Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again". J. Clin. Invest. 114 (10): 1414–7. doi:10.1172/JCI200423586. PMC 525752. PMID 15545992. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=525752.
  3. Delarue J, Magnan C (2007). "Free fatty acids and insulin resistance". Current opinion in clinical nutrition and metabolic care 10 (2): 142–8. doi:10.1097/MCO.0b013e328042ba90. PMID 17285001.
  4. Randle PJ, Garland PB, Hales CN, Newsholme EA (1963). "The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus". Lancet 1 (7285): 785–9. doi:10.1016/S0140-6736(63)91500-9. PMID 13990765.





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