2011-04-25

Ifex/Mesnex Kit

Ifosfamide

Ifosfamide
Systematic (IUPAC) name
N-3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide-2-oxide
Identifiers
CAS number 3778-73-2
ATC code L01AA06
PubChem CID 3690
DrugBank APRD00007
ChemSpider 3562
UNII UM20QQM95Y
KEGG D00343
ChEMBL CHEMBL1024
Synonyms 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Chemical data
Formula C7H15Cl2N2O2P
Mol. mass 261.1
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 100%
Metabolism Hepatic
Half-life 60-80% in 72 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat. ?
Legal status ?
Routes intravenously
Yes(what is this?) (verify)

Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer.

It is sometimes abbreviated "IFO".

Uses

It is given as a treatment for a variety of cancers, including:

Administration

It is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous.

Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.

References

External links






Retrieved from : http://en.wikipedia.org/wiki/Ifosfamide