|FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)|
SAC domain-containing protein 3 belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells.
Fig4 exists in a complex with the lipid kinase PIKFYVE and the scaffolding protein Vac14 in yeast, this complex also contains Atg18 and Vac7. The roles of the mammalian orthologues of Vac7 and Atg18 have not yet been established.
Mutations in this gene have been associated with Charcot–Marie–Tooth disease, type 4J.
Retrieved from : http://en.wikipedia.org/wiki/Fig4