Demykon

Chlorphenesin

Chlorphenesin

Systematic (IUPAC) name
(3-(4-chlorophenoxy)-2-hydroxypropyl)carbamate
Identifiers
CAS number	886-74-8
ATC code	D01AE07
PubChem	CID 2724
ChemSpider	2623
KEGG	D00770
ChEMBL	CHEMBL607710
Chemical data
Formula	C10H12ClNO4
Mol. mass	245.660 g/mol
SMILES	eMolecules & PubChem
Physical data
Melt. point	86–92 °C (187–198 °F)
Pharmacokinetic data
Excretion	urine
Therapeutic considerations
Pregnancy cat.	?
Legal status	?

Chlorphenesin (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms.

It also has antifungal and some antibacterial properties and is thus classified as an antifungal for topical use by the WHO.

Safety

The adverse effects from this preservative on skin is allergic contact sensitivity.

Physical Properties

Melting Point

86–92 deg. Celsius

Chemistry

Chlorphenesin, 3-(4-chlorophenoxy)-1,2-propanediol, is synthesized in the same manner as methocarbamol from 3-(4-chlorophenoxy)-1,2-propanediol.

References

1. Okuyama S, Aihara H (1987). "Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats". Research communications in chemical pathology and pharmacology 55 (2): 147–60. PMID 3823606.
2. Kurachi M, Aihara H (1984). "Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats". Japanese journal of pharmacology 36 (1): 7–13. PMID 6503049.
3. ATC code D01AE07
4. Brown R (1981). "Chlorphenesin sensitivity". Contact Dermatitis 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118.
5. Burns DA (1986). "Allergic contact sensitivity to chlorphenesin". Contact Dermatitis 14 (33): 246. doi:10.1111/j.1600-0536.1986.tb01234.x. PMID 2941223.
6. Salim E.F., Booth R.E. (1967). "Qualitative and quantitative tests for chlorphenesin carbamate". Journal of Pharmaceutical Sciences 56 (5): 623. doi:10.1002/jps.2600560516. PMID 6032776. http://www3.interscience.wiley.com/journal/113292953/abstract. Retrieved 2009-06-23.

Retrieved from : http://en.wikipedia.org/wiki/Chlorphenesin