Bezafibrate
 | |
|---|---|
| Systematic (IUPAC) name | |
| 2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropanoic acid | |
| Identifiers | |
| CAS number | 41859-67-0 |
| ATC code | C10AB02 |
| PubChem | CID 39042 |
| ChemSpider | 35728 |
| UNII | Y9449Q51XH |
| ChEMBL | CHEMBL264374 |
| Chemical data | |
| Formula | C19H20ClNO4 |
| Mol. mass | 361.819 g/mol |
| SMILES | eMolecules & PubChem |
| Therapeutic considerations | |
| Pregnancy cat. | ? |
| Legal status | POM (UK) ℞-only (US) |
| Routes | Oral |
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Bezafibrate (marketed as Bezalip and various other brand names) is a fibrate drug used for the treatment of hyperlipidaemia. It helps to lower LDL cholesterol and triglyceride in the blood, and increase HDL.
History
Bezafibrate was first introduced by Boehringer Mannheim in 1977.
Mode of action
Like the other fibrates, bezafibrate is an agonist of PPARα; some studies suggest it may have some activity on PPARγ and PPARδ as well.
Uses
Bezafibrate improves markers of combined hyperlipidemia, effectively reducing LDL and triglycerides and improving HDL levels. The main effect on cardiovascular morbidity is in patients with the metabolic syndrome, the features of which are attenuated by bezafibrate. Studies show that in patients with impaired glucose tolerance, bezafibrate may delay progress to diabetes, and in those with insulin resistance it slowed progress in the HOMA severity marker.
Side-effects
The main toxicity is hepatic (abnormal liver enzymes), and myopathy and rarely rhabdomyolysis have been reported.
Other uses
The Australian biotech company Giaconda combines bezafibrate with chenodeoxycholic acid in an anti-hepatitis C drug combination called Hepaconda.
References
- "Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study". Circulation 102 (1): 21–7. 2000. PMID 10880410.
- Tenenbaum, A; Motro, M; Fisman, EZ; Tanne, D; Boyko, V; Behar, S (2005). "Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome". Archives of internal medicine 165 (10): 1154–60. doi:10.1001/archinte.165.10.1154. PMID 15911729.
- Tenenbaum, A; Motro, M; Fisman, EZ; Schwammenthal, E; Adler, Y; Goldenberg, I; Leor, J; Boyko, V et al. (2004). "Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease". Circulation 109 (18): 2197–202. doi:10.1161/01.CIR.0000126824.12785.B6. PMID 15123532.
- Tenenbaum, A; Fisman, EZ; Boyko, V; Benderly, M; Tanne, D; Haim, M; Matas, Z; Motro, M et al. (2006). "Attenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate". Archives of internal medicine 166 (7): 737–41. doi:10.1001/archinte.166.7.737. PMID 16606809.
Retrieved from : http://en.wikipedia.org/wiki/Bezafibrate
