Ifosfamide
 | |
|---|---|
| Systematic (IUPAC) name | |
| N-3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide-2-oxide | |
| Identifiers | |
| CAS number | 3778-73-2 |
| ATC code | L01AA06 |
| PubChem | CID 3690 |
| DrugBank | APRD00007 |
| ChemSpider | 3562 |
| UNII | UM20QQM95Y |
| KEGG | D00343 |
| ChEMBL | CHEMBL1024 |
| Synonyms | 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide |
| Chemical data | |
| Formula | C7H15Cl2N2O2P |
| Mol. mass | 261.1 |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | 100% |
| Metabolism | Hepatic |
| Half-life | 60-80% in 72 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | intravenously |
 (what is this?) (verify) | |
Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer.
It is sometimes abbreviated "IFO".
Uses
It is given as a treatment for a variety of cancers, including:
Administration
It is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous.
Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.
References
External links
- ACS Drug Guide: Ifosfamide
- Harvard Medical School Health Information on Ifosfamide
- MedlinePlus Drug Information
- BC Cancer Agency Ifosamide Information (Professional)
- RxList Online Drug Index Ifosamide Listing
Retrieved from : http://en.wikipedia.org/wiki/Ifosfamide
